Curculigoside attenuates cerebral ischemia-reperfusion injury via TRPM2-mediated microglial polarization

Mengying Fan, Yangyang Chen, Pingping Yin, Peng Li, Department of Anesthesiology, Wuhan Fourth Hospital, Hubei Province, Department of Pain Management, Wuhan Fourth Hospital, Hubei Province

Human & Experimental Toxicology

Published online on February 26, 2026

Abstract

Human & Experimental Toxicology, Volume 45, January-December 2026.
ObjectiveCerebral ischemia-reperfusion injury (CIRI) remains a major challenge in clinical practice, without effective and targeted approaches to address it. Curculigoside has been reported to exert beneficial effects in CIRI, yet the underlying novel ...