Pulmonary iron oxide (Fe3O4) nanoparticle-biomolecule interactions modified during aging and metabolic syndrome disease progression

Akshada Shinde, Li Xia, Venkatesh P. Thirumalaikumar, Christina R. Ferreira, Nadia Lanman, Jonathan Shannahan, School of Health Sciences, Purdue University, West Lafayette, Purdue Proteomic Profiling Facility, Purdue University, West Lafayette, Purdue Metabolite Profiling Facility, Purdue University, West Lafayette, Purdue University Institute for Cancer Research and the Department of Comparative Pathobiology, Purdue University, West Lafayette

Human & Experimental Toxicology

Published online on January 19, 2026

Abstract

Human & Experimental Toxicology, Volume 45, January-December 2026.
IntroductionAging and metabolic disease enhance inhaled particulate toxicity. Nanoparticles (NPs) are rapidly coated with biomolecules forming a biocorona (BC), upon entering the body and may contribute to the susceptibility. Aging and metabolic syndrome (...