Inhibition of store-operated calcium entry mitigates lipopolysaccharide-induced hepatotoxicity via modulating inflammatory and oxidative stress responses

Mohammed Alqinyah, Abdullah S. Alhamed, Yasseen A. Alassmrry, Mohamed Mohany, Khaldoon Aljerian, Khalid Alhazzani, Mohammad M. Algahtani, Hussain N. Alhamami, Ahmed Z. Alanazi, Faris Almutairi, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Saudi Arabia, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, John Dossetor Health Ethics Center, University of Alberta

Human & Experimental Toxicology

Published online on January 09, 2026

Abstract

Human & Experimental Toxicology, Volume 45, January-December 2026.
IntroductionHepatotoxicity can arise secondary to several medical conditions, including inflammation, sepsis, and therapy. Lipopolysaccharide (LPS) can activate diverse inflammatory pathways and has been implicated in hepatotoxicity. The store-operated ...