Prediction of Specific Survival and Clinicopathological Impact of Somatic PALB2 Mutations and Pathogenic/Likely Pathogenic Variants (PV/LPV) in Breast Cancer: A Cohort Study of 81 Patients

Yousef M. Hawsawi, Ibrahim Mansoor, Mutlay Sayan, Mansour Alsaleem, Mohammed Imran Khan, Rimah Abdullah Saleem, Abeer Zakariyah, Fahad Nasser Alonazi, Raghad Yousef Alnader, Ahmed Noorsaeed, Abdelrazak Meliti, Muhammad Imran Naseer, Hosam Alardati, Munaifah K. Alanezi, Nuha Shaker, Nada Shaker

International Journal of Surgical Pathology

Published online on March 13, 2026

Abstract

International Journal of Surgical Pathology, Ahead of Print.
PALB2plays a crucial role in DNA repair by interacting withBRCA1andBRCA2. To clarify the clinicopathological impact of somatic PALB2 variants, we analyzed tumor DNA extracted from formalin-fixed, paraffin-embedded (FFPE) breast cancer specimens from ...