Advanced Glycation End Products Induce Cuproptosis and Then Promote the Activation and Migration of Cardiac Fibroblasts

Jian Xiao, Zan-hua Shi, Xin-hua Ma, Dao-miao Xu, Guang-feng Ming, Department of Critical Care Medicine, Xiangya Hospital, Central South University, Department of Pharmacy, Xiangya Hospital, Central South University, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Department of Neurosurgery, Xiangya Hospital, Central South University

International Journal of Toxicology

Published online on April 21, 2026

Abstract

International Journal of Toxicology, Ahead of Print.
Excessive advanced glycation end products (AGEs) can lead to cardiovascular diseases such as myocardial fibrosis (MF). Although studies have found that AGEs induce cuproptosis, and cuproptosis promotes fibrosis, it has not been confirmed whether AGEs ...