Sub-Cytotoxic Mitochondrial Stress in Cardiomyocytes and Whole-Organism Toxicity in C. elegans Induced by Molnupiravir

Zehra Keskin, Ebru Didem Kuran, Meltem Gulec, Gul Ozhan, Aysenur Gunaydin-Akyildiz, Institute of Graduate Studies in Health Sciences, Istanbul University, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Bezmialem Vakif University, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Fenerbahce University, Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University-Cerrahpaşa, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University-Cerrahpaşa

International Journal of Toxicology

Published online on April 09, 2026

Abstract

International Journal of Toxicology, Ahead of Print.
Many antiviral agents are known to induce off-target mitochondrial toxicity due to the prokaryotic origin of mitochondria. Mitochondrial dysfunction is frequently linked to cardiotoxicity. We aimed to elucidate the mitochondrial toxicity profile of ...