5-Methoxy-N,N-Dimethyltryptamine: Functional Safety Pharmacology and Video-EEG Assessment of a Short-Acting Serotonergic Psychedelic in Beagle Canines

Amir Lotfi, Samantha Sparapani, Mylene Pouliot, Yifei Zhong, Stephen Montgomery, Simon Authier, Beckley Psytech Limited, United Kingdom of Great Britain and Northern Ireland, Charles River Laboratories, Independent Consultant, Usa Ma

International Journal of Toxicology

Published online on January 31, 2026

Abstract

International Journal of Toxicology, Ahead of Print.
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a serotonin receptor agonist, in clinical development for the treatment of major depression and other psychiatric disorders. A critical safety concern for serotonergic compounds is their potential to induce ...