Ozone Preexposure Exacerbates Septic Lung Injury Through ADAR1 Modulation and Pyroptosis Activation

Quanzhen Wang, Yajun Liu, Yuke Zhang, Lei Zhou, Tiangang Zhou, Fen Liu, Huanqin Chen, Zhiming Jiang, Department of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University, Department of Respiratory Intensive Care Unit, The First Affiliated Hospital of Shandong First Medical University, Department of Emergency Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Gerontology, Qilu Hospital, Shandong University

International Journal of Toxicology

Published online on November 13, 2025

Abstract

International Journal of Toxicology, Volume 45, Issue 2, Page 198-211, March/April 2026.
Chronic ozone exposure in urban environments compromises lung function, predisposing individuals to severe sepsis outcomes from common infections. Pyroptosis, a type of programmed cell death, is implicated in sepsis and lung injury, and its regulation is ...