3D GelMA–Chitosan constructs regulate mesenchymal stem cell fate via YAP-dependent mechanotransduction for spinal cord injury repair

Qinglin Luo, Xiangyong Que, You Zhou, Maopeng Wang, Xiaokang Zhu, Han Wang, Jingwei Jiu, Xinzhi Li, Department of Orthopedics, Renhe Hospital Affiliated to China Three Gorges University, Department of Oncology, Renhe Hospital Affiliated to China Three Gorges University, Department of Orthopedics, The Second Hospital of Shanxi Medical University, College of Health Medicine, China Three Gorges University

Journal of Biomaterials Applications

Published online on April 24, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
Spinal cord injury (SCI) results in irreversible neuronal loss, cystic cavitation, and a chronically hostile microenvironment that severely limits endogenous repair. Conventional stem cell transplantation is frequently compromised by low cell survival, ...