Zoledronic acid/cisplatin-loaded cucurbit[7]uril-modified upconversion nanoformulations drive tumor-associated macrophage polarization and potentiate the efficacy of cancer immunotherapy

Yakun Ge, Pengcheng Li, Jiatong Zhang, Ruolan Wang, Renwen Zhang, Hongyu Xu, Zhenming Hao, Yuanxin Zhang, College of Biological and Food Engineering, Jilin University of Chemical Technology

Journal of Biomaterials Applications

Published online on January 31, 2026

Abstract

Journal of Biomaterials Applications, Volume 41, Issue 2, Page 259-272, August 2026.
Tumor-associated macrophages (TAMs) play a pivotal role in establishing a tumor immunosuppressive microenvironment (TIME) by inducing a phenotypic shift in macrophage from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. This polarization ...