Development and evaluation of a fish skin-derived acellular dermal matrix for diabetic wound healing: In vitro and in vivo assessment

Mekha Grace Varghese, Thomas George Valliaveettil, Binsi Puthanpurakkalkizhakkethil Kamalamma, Nibu Varghese, Yogesh Bharat Dalvi, Nebu George Thomas, Rajasree Anitha Rajeevan, Anoop Chandran, Sukumaran Anil, Stem cell and tissue engineering lab, Pushpagiri Research Center, Pushpagiri Institute of Medical Sciences and Research Centre, Department of Periodontology, Pushpagiri College of Dental Sciences, Fish Processing Division, Central Institute of Fisheries Technology, and Research Department of Physics, St Cyril, s College, Department of Dentistry, Oral Health Institute, Hamad Medical Corporation

Journal of Biomaterials Applications

Published online on January 30, 2026

Abstract

Journal of Biomaterials Applications, Volume 41, Issue 2, Page 221-232, August 2026.
Introduction:Non-healing diabetic foot ulcers often result in amputation and reduced quality of life. The study objective was to develop and evaluate a novel fish skin-derived acellular dermal matrix (FSADM) for diabetic wound-healing applications, ...