Multicomponent scaffold with hierarchical porosity for enhanced mechanical and bioactivity

Hong Chen, Ying Huang, Changzhi Huang, Yuanqing Cai, Yang Chen, Yonggang Yan, Xinyu Fang, Wenming Zhang, Department of Orthopaedics Surgery, The First Affiliated Hospital, Fujian Medical University, Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fujian Orthopaedics Research Institute, the First Affiliated Hospital, Fujian Medical University, Department of Joint Surgery and Sports Medicine, Ningde Municipal Hospital of Ningde Normal University, College of Physics, Sichuan University

Journal of Biomaterials Applications

Published online on December 26, 2025

Abstract

Journal of Biomaterials Applications, Volume 41, Issue 1, Page 80-95, July 2026.
The repair of critical-sized bone defects remains challenging due to insufficient blood vessel formation and nutrient delivery. To overcome this limitation, we developed a porous organic/inorganic composite scaffold, named Micro-MP, through a combined ...