Synergistic effects of biosynthesized gold nanoparticles with curcumin on motor, inflammatory, and oxidative parameters in a Parkinson’s disease model

Paulo Cesar Lock Silveira, Ligia Milanez Venturini, Gustavo de Bem Silveira, Igor Ramos Lima, Camila da Costa, Gabrielli Martins, Laura de Roch Casagrande, Ellen De Pieri, Paulo Emilio Feuser, Yaodong Gu, Ricardo Andrez Machado-de-Ávila, Anand Thirupathi, Faculty of Sports Science, Ningbo University, Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense

Journal of Biomaterials Applications

Published online on December 23, 2025

Abstract

Journal of Biomaterials Applications, Volume 41, Issue 1, Page 134-148, July 2026.
Parkinson’s disease is a progressive and irreversible neurodegenerative disease, whose main characteristic is the death of dopaminergic neurons. The animal model of Parkinsonism with reserpine has been used to mimic the consequences of Parkinson’s ...