Lipoic acid and melatonin co-loaded chitosan nanoparticles in alginate hydrogel: A multifunctional dressing for diabetic wound management

Yankui Liu, Guang Wang, Xinhui Hu, Zhaoxiang Wu, Department of Emergency Surgery, Yunnan University Affiliated Hospital, Department of Urology, The Second Affiliated Hospital of Kunming Medical University

Journal of Biomaterials Applications

Published online on December 30, 2025

Abstract

Journal of Biomaterials Applications, Volume 41, Issue 2, Page 304-321, August 2026.
BackgroundImpaired wound healing in diabetic patients remains a major clinical challenge due to oxidative stress, chronic inflammation, and compromised tissue regeneration.ObjectiveThis study aimed to develop and evaluate a novel nanocomposite hydrogel ...