Glutathione-coated titanium implants promote bone defect repair through antioxidant stress

Tianran Wang, Tao Jiang, Junyong Ge, Zhansong Tian, Shiwu Dong, Xiang Ao, Shouqi Sun, Yu Wang, Cheng Yu, Zhaxi Mima, Department of Orthopedics, Shigatse Branch, Xinqiao Hospital, Third Military Medical University , Army Medical University, Department of Orthopedics, Third Affiliated Hospital of Naval Medical University, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University , Army Medical University

Journal of Biomaterials Applications

Published online on January 09, 2026

Abstract

Journal of Biomaterials Applications, Volume 41, Issue 1, Page 106-122, July 2026.
Elevated levels of reactive oxygen species (ROS) in the bone defect area impede bone regeneration and repair. Although titanium and its alloys are widely used for bone defect repair, they lack bioactivity and the ability to scavenge ROS at the defect site,...