Impact of excipient differences on the clinical performance of generic oral formulations: A narrative review and descriptive comparison

Eri Inahara, Ryuto Ohashi, Takayuki Omori, Takuro Kurita, Takanori Nakajima, Yusuke Takizawa, Division of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Nihon Pharmaceutical University, Division of Practical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Nihon Pharmaceutical University

Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector

Published online on November 22, 2025

Abstract

Journal of Generic Medicines, Volume 22, Issue 1, Page 13-22, March 2026.
Generic substitution is widely promoted to contain healthcare costs, yet variability in excipient composition across formulations has raised clinical concerns. This study aimed to highlight how excipient differences may relate to clinical observations ...