Peripheral Blood Epigenetic Age Acceleration is Associated With Psychosis in Female APOE4 Carriers With Mild Cognitive Impairment and Alzheimer’s Disease: A Pilot Study

Dylan Kwan, Neda Rashidi-Ranjbar, Joseph E. Marinas, Andrew Namasivayam, Nathan Churchill, Luis R. Fornazzari, Zahinoor Ismail, Vincenzo DeLuca, Tom A. Schweizer, David G. Munoz, Corinne E. Fischer, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, s Hospital, Michael G. DeGroote School of Medicine, McMaster University, Faculty of Medicine, Department of Psychiatry, University of Toronto, Faculty of Medicine, Department of Neurology, University of Toronto, Cumming School of Medicine, Department of Psychiatry, University of Calgary, Hotchkiss Brain Institute, University of Calgary, Institute of Medical Sciences, University of Toronto, Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Department of Laboratory Medicine and Pathobiology, Division of Pathology, s Hospital

Journal of Geriatric Psychiatry and Neurology

Published online on February 07, 2026

Abstract

Journal of Geriatric Psychiatry and Neurology, Ahead of Print.
ObjectivePsychosis is a significant neuropsychiatric symptom in Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). While female APOE4 homozygotes are at the highest risk of psychosis, mechanisms underlying this association remain unclear. We ...