Evaluating Physical Frailty as a Marker of Cognitive Health in Older Adults without Dementia

Youngmin Cho, Jing Huang, Sofia Liu, Nada Lukkahatai, Jessica Gill, Junxin Li, School of Nursing, Johns Hopkins University, Department of Neurology, School of Medicine, Johns Hopkins University

Journal of Geriatric Psychiatry and Neurology

Published online on January 27, 2026

Abstract

Journal of Geriatric Psychiatry and Neurology, Ahead of Print.
Physical frailty is associated with adverse health outcomes in older adults, including cognitive decline; however, the underlying biological and pathophysiological mechanisms linking frailty to neuropathological biomarkers remain underexplored, ...