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Type and Size of Fluorescent Proteins Modulate the Localization of PTEN and Its Fragments, but Have Little or No Effect on Mutant PTEN or Stressed Cells

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Journal of Histochemistry & Cytochemistry

Published online on

Abstract

Journal of Histochemistry & Cytochemistry, Ahead of Print.
The functions of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumor suppressor, depend on its subcellular localization. At the plasma membrane, PTEN dephosphorylates phosphatidylinositol-3,4,5-triphosphate to inhibit AKT signaling, ...