Advancing Microcirculatory Therapies in Pediatric Sepsis: Current Opportunities and Future Directions

Carolina Casas, Jaime Fernández-Sarmiento, Mauricio Sarta-Mantilla, Hernando Mulett, Lorena Acevedo, Briam Beltrán, Juanita Medina, Clarisel Del Carmen Compres, Piera Nathalie Serrano, María Elvira Sarta-Mantilla, Valentina Pérez, Maria Camila Gomez, Maria Carolina Niño, Cielo Cuadros, Maria José Barrera, Natalia Pedraza-López, Joseph A. Carcillo

Journal of Intensive Care Medicine

Published online on May 30, 2025

Abstract

Journal of Intensive Care Medicine, Ahead of Print.
Microcirculatory dysfunction in pediatric sepsis is a key factor in the development of tissue hypoperfusion and multiple organ failure. Endothelial glycocalyx alteration, increased capillary permeability, and blood flow heterogeneity are common findings ...