Incidence of Acute Kidney Injury (AKI) in Critically Ill Patients Receiving Concomitant Vancomycin with Piperacillin-Tazobactam or Cefepime; a Systemic Review and Meta-analysis

Lamees Alaradi, Nada Albariqi, Mona Alanazi, Naif Alghassab, Tief Aseri, Lujain Alahmadi, Ahmad Alahmadi, Aseel Althobaiti, Yousef Alqarafi, Habeeba Bokhari, Rayan A Qutob, Mohanad Almaimani

Journal of Intensive Care Medicine

Published online on March 24, 2025

Abstract

Journal of Intensive Care Medicine, Volume 41, Issue 6, Page 447-455, June 2026.
Background:Nephrotoxicity remains a significant concern in the management of critically ill patients receiving antibiotic therapy. The combination of Vancomycin and Piperacillin-Tazobactam (VPT) is frequently employed to combat multidrug-resistant ...