Ketamine and Esketamine for the Prevention of Delirium in Surgical Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Nestor Cordeiro dos Santos Neto, Raimundo Pires Montenegro Neto, Esther Frota Gomes, Marina Carvalho Lima Mendonça, Diego Bastos Porto, Manoel Amora Albano Amora Neto, Lucilaide Oliveira Santos, Hildegard Loren Rebouças Santos

Journal of Intensive Care Medicine

Published online on January 07, 2026

Abstract

Journal of Intensive Care Medicine, Ahead of Print.
BackgroundDelirium is a common and serious complication in critically ill and surgical patients, associated with increased morbidity, prolonged hospitalization, and long-term cognitive impairment. Ketamine and esketamine have been proposed as potential ...