Angiotensin-(1–7) suppresses pyroptosis in cerebral endothelium to decrease blood–brain barrier permeability and cognitive impairments in sepsis

Yongli Han, Hongguang Ding, Yirun Chen, Yin Wen, Huishan Zhu, Zhiwei Su, Jiaqi Tang, Hongke Zeng, Department of Critical Care Medicine, Guangdong Provincial People, s Hospital , Guangdong Academy of Medical Sciences, Southern Medical University, Department of Emergency Medicine, Guangdong Provincial People, s Hospital , Guangdong Academy of Medical Sciences, Southern Medical University, Department of Critical Care Medicine, The Second Affiliated Hospital of Shantou University Medical College

Journal of International Medical Research

Published online on April 30, 2026

Abstract

Journal of International Medical Research, Volume 54, Issue 4, April 2026.
ObjectiveThis study aimed to explore the influence of the angiotensin-(1–7)/Mas receptor and angiotensin II/angiotensin II type 1 receptor pathways on pyroptosis during sepsis and their subsequent effects on cognitive function.MethodsAdult C57BL/6 mice ...