<abstract>

Aim of the study:Traditionally herbal formulations have been used effectively for

the management of disorders that are now being accepted worldwide.

Saraca asoca bark extract (SAE) finds use in traditional

herbal medicine. In the present study, SAE were studied for their antioxidant,

antimutagenic, and antigenotoxic properties.

Methods:SAE were evaluated for antimutagenic property in

Salmonella strains (TA97a, TA98, TA100, and TA102), in the

presence and absence of metabolic activation (S9). The SAE was also studied for

antigenotoxic property against cyclophosphamide (CP) in Swiss albino male mice

in vivo. The extract was analyzed using high-performance

liquid chromatography (HPLC).

Results: The study reveals antimutagenic property of the bark extract in

Salmonella strains in the presence and absence of metabolic

activation (S9). The study reports antigenotoxic property of the bark extract

against CP in vivo. Thiobarbituric acid reactive species assay

on the bark extract revealed antioxidant property. HPLC revealed the presence of

two peaks corresponding to gallic acid and (-)-epicatechin, respectively.

Conclusion: The study clearly reveals the antimutagenic and antigenotoxic

properties of SAE.

</abstract>