Serum metabolic profile at clinical onset as predictor of multiple sclerosis activity and progression after 5 years

Xiaojing Peng, Kjetil Bjornevik, Clary B Clish, Gilles Edan, Mark S Freedman, Hans-Peter Hartung, Xavier Montalbán, Rupert Sandbrink, Jens Kuhle, Frederik Barkhof, Eva-Maria Wicklein, Ludwig Kappos, Alberto Ascherio, Marianna Cortese

Multiple Sclerosis Journal

Published online on April 26, 2026

Abstract

Multiple Sclerosis Journal, Ahead of Print.
Background:Metabolic dysregulations have been reported in multiple sclerosis (MS), but it is unclear whether metabolic profiles at disease onset predict long-term outcomes.Objectives:We evaluated whether baseline metabolic profiles at MS onset could ...