Diagnostic performance of central vein sign and paramagnetic rim lesion integration for multiple sclerosis

Karlo Toljan, Brian Renner, Lynn Daboul, Melissa L Martin, Quy Cao, Carly M O, Paulo Rodrigues, John Derbyshire, Christina J Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter A Calabresi, Bruce A C Cree, Leorah Freeman, Roland G Henry, Erin E Longbrake, Kunio Nakamura, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D Samudralwar, Matthew K Schindler, Elias S Sotirchos, Nancy L Sicotte, Andrew J Solomon, Russell T Shinohara, Daniel S Reich, Pascal Sati, Daniel Ontaneda

Multiple Sclerosis Journal

Published online on April 21, 2026

Abstract

Multiple Sclerosis Journal, Ahead of Print.
Background:The central vein sign (CVS) and the paramagnetic rim lesion (PRL) are neuroimaging biomarkers of multiple sclerosis (MS).Objectives:To determine the diagnostic performance of CVS and PRL integration in people presenting for initial diagnostic ...