A multi-modal deep learning network for the classification of paramagnetic rim and remyelinated lesions in multiple sclerosis

Federico Spagnolo, Pedro M Gordaliza, Aarushi Bhardwaj, Po-Jui Lu, Mario Ocampo-Pineda, Meritxell Bach Cuadra, Matthias Weigel, Esther Ruberte, Xinjie Chen, Tommaso Sirito, Alessandro Cagol, Vincent Andrearczyk, Adrien Depeursinge, Cristina Granziera

Multiple Sclerosis Journal

Published online on March 07, 2026

Abstract

Multiple Sclerosis Journal, Ahead of Print.
Objectives:Robust automated classification of paramagnetic rim lesions (PRLs) and remyelinated lesions based on iron and myelin content in people with multiple sclerosis (pwMS).Materials and Methods:In this prospective study (2018–2022), three-dimensional ...