Comparison of individuals with radiologically isolated syndrome, early multiple sclerosis patients, and healthy controls using a digital neurological examination

Mikael Cohen, Lydiane Mondot, Xavier Ayrignac, Sandra Vukusic, Bertrand Bourre, Elisabeth Maillart, Hélène Zephir, Laure Michel, Eric Thouvenot, Parker Rice, Aurélie Hohweiller, Darin T Okuda, Cassandre Landes Château, Christine Lebrun Frenayon behalf SFSEP and RISC

Multiple Sclerosis Journal

Published online on February 23, 2026

Abstract

Multiple Sclerosis Journal, Ahead of Print.
Background:The revised McDonald criteria shifted toward the recognition of the radiologically isolated syndrome (RIS) as the first phase of the multiple sclerosis (MS) spectrum.Objectives:To characterize differences between RIS individuals, early MS ...