Prolonged Agitation and Hypotonia due to Baclofen and Tizanidine Overdose Followed by Withdrawal: A Case Report

Samuele Bonomi, Giorgio Guido, Ashley M. Jones, Savannah Seupaul, Michael E. Mullins, Department of Neurology, Barnes-Jewish Hospital, Washington University School of Medicine in St, Neurology Unit, IRCCS San Raffaele Scientific Institute in Milan, Saint Louis University School of Medicine, Saint Louis, Department of Emergency Medicine, Washington University School of Medicine in St, Saint Louis

The Neurohospitalist

Published online on April 18, 2026

Abstract

The Neurohospitalist, Ahead of Print.
We describe a unique case of combined baclofen and tizanidine overdose followed by dual withdrawal syndromes, highlighting overlapping and contrasting clinical features that may complicate diagnosis and management. A 26-year-old man with paraplegia from ...