Subacute Combined Degeneration From Isolated Folate Deficiency Secondary to Nutrition and Co-Trimoxazole Use in a Patient With IgG4-Related Disease

Manta Yonpiam, Thanakit Pongpitakmetha, Wattakorn Laohapiboolrattana, Anand Viswanathan, Jakkrit Amornvit, Faculty of Medicine, Chulalongkorn University, Buddhasothorn Hospital, Ministry of Public Health, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Comprehensive Headache and Orofacial Pain , Service and Research Group, Faculty of Medicine, Chulalongkorn University, Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Division of Neurology, Department of Medicine, Faculty of Medicine, Naresuan University, Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School

The Neurohospitalist

Published online on September 24, 2025

Abstract

The Neurohospitalist, Volume 16, Issue 2, Page 208-212, April 2026.
Subacute combined degeneration (SCD) is characterized by demyelination primarily affecting the dorsal column and lateral corticospinal tracts. It typically presents with paresthesia in the feet and progresses to involve the upper extremities. SCD is ...