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Perineuronal Nets: Old Structures, New Functions

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The Neuroscientist: Reviews at the Interface of Basic and Clinical Neurosciences

Published online on

Abstract

The Neuroscientist, Volume 32, Issue 3, Page 169-183, June 2026.
Perineuronal nets (PNNs) are morphologically distinct aggregates of extracellular matrix that predominantly ensheath fast-spiking GABAergic neurons in the brain. Discovered in the late 19th century by Camilo Golgi, PNNs have emerged as an important ...