How Do Amyloid Pathology and Aberrant Neuronal Activity Disrupt Plasticity and Memory in Alzheimer’s Disease?
The Neuroscientist: Reviews at the Interface of Basic and Clinical Neurosciences
Published online on January 31, 2026
Abstract
The Neuroscientist, Volume 32, Issue 2, Page 112-125, April 2026.
Alzheimer’s disease (AD) is increasingly understood as a disorder of network-state and plasticity-capacity, in which amyloid-β and tau pathologies disrupt the activity-dependent mechanisms that build and stabilize memory engrams. Here, I review how ...
Alzheimer’s disease (AD) is increasingly understood as a disorder of network-state and plasticity-capacity, in which amyloid-β and tau pathologies disrupt the activity-dependent mechanisms that build and stabilize memory engrams. Here, I review how ...