A randomized controlled clinical trial of intranasal versus subcutaneous midazolam for agitation in terminal illness (MinTU study)

Hanna Hirschinger, Constanze Rémi, Evelyn Jäger, Stefanie Nittka, Svetlana Hetjens, Susanne Saussele, Kirsten Merx, Jan Koch, Mohammed Abba, Mahmoud Ghazal, Ralf-D Hofheinz, Thomas Michaeli, Elena Sperk, Katharina Kohlbrenner, Wolf-K Hofmann, Deniz Gencer, Tobias Boch

Palliative Medicine: The Research Journal of the EAPC - A Multiprofessional Journal

Published online on March 23, 2026

Abstract

Palliative Medicine, Volume 40, Issue 6, Page 856-867, June 2026.
Background:Terminally ill patients often have difficulty taking medications. Suitable, minimally invasive, fast-acting administration routes are particularly important. Trials on alternative drug administration routes in palliative care are essential to ...