Dabigatran-idarucizumab pharmacokinetics-pharmacodynamics in sheep undergoing cardiopulmonary bypass

Michael P Eaton, Sergiy M Nadtochiy, Tatsiana Stefanos, Brian J Anderson, University of Rochester School of Medicine and Dentistry, Department Anesthesiology, University of Auckland, New Zealand

Perfusion

Published online on December 01, 2025

Abstract

Perfusion, Ahead of Print.
BackgroundThe effect of the anticoagulant, dabigatran, and its antagonist, idarucizumab, on coagulation remains poorly quantified. There are few pharmacokinetic-pharmacodynamic data available to describe the interaction in humans or animals undergoing ...