Towards goal-directed perfusion - Part II: Temperature dependence of Q10, oxygen-demand dependence on age and weight, further clinical insights

Mansour T. A, Alireza S. Mahani, Richard W. Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica, School of Public Health, Imperial College, New York Stock Exchange, New York, Centre for Heart Failure, Transplantation and Extracorporeal Support, UCL Institute for Cardiovascular Science, Perfusion Department, Great Ormond Street Hospital for Children, Data Research, Innovation and Virtual Environments Unit, Great Ormond Street Hospital for Children, Cardiac Surgery Department, Great Ormond Street Hospital for Children, Cardiac Surgery Department, Bristol Royal Children, s Hospital

Perfusion

Published online on October 14, 2025

Abstract

Perfusion, Ahead of Print.
BackgroundGoal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) seeks to match oxygen delivery with patient-specific metabolic demand, yet determinants of oxygen demand and dynamics of oxygen extraction ratio (OER) are not well characterised ...