Towards goal-directed perfusion – Part I: Developing physiology-inspired mathematical framework using high-resolution paediatric CPB data

Mansour T. A, Alireza S. Mahani, Richard W. Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica, School of Public Health, Imperial College, New York Stock Exchange, New York, Centre for Heart Failure, Transplantation and Extracorporeal Support, UCL Institute for Cardiovascular Science, Perfusion Department, Great Ormond Street Hospital for Children, Data Research, Innovation and Virtual Environments Unit, Great Ormond Street Hospital for Children, Cardiac Surgery Department, Great Ormond Street Hospital for Children, Cardiac Surgery Department, Bristol Royal Children, s Hospital

Perfusion

Published online on September 10, 2025

Abstract

Perfusion, Ahead of Print.
BackgroundDuring cardiopulmonary bypass (CPB), goal-directed perfusion (GDP) seeks to match oxygen delivery to metabolic demand, but the dynamics of oxygen extraction and intraoperative oxygen demand remain poorly understood, especially in paediatric ...