Hyperthermic Extracorporeal Applied Tumor Therapy (HEATT®) in hospice- eligible cancer patients

Joseph B. Zwischenberger, Peyton Mashni, Robert Fischer, Joanne Essa, Sarah Hatchett, Jan Winetz, Roger Vertrees, Department of Surgery, University of Kentucky, College of Medicine, University of Kentucky, First Baptist Medical Center, University of Kentucky, Verthermia Corporation

Perfusion

Published online on January 08, 2026

Abstract

Perfusion, Ahead of Print.
BackgroundTwo previous clinical studies indicated veno-venous perfusion-induced systemic hyperthermia (VV-PISH), producing elevated temperatures of 42°C, induces cell death, apoptosis, or senescence of responsive cancers. The VV-PISH circuit has been ...