Preparation of a cardiopulmonary bypass priming solution for infants and neonates – effect of pre-bypass ultrafiltration on heparinization

Paul G. Davies, Suelyn Van Den Helm, Natasha Letunica, Shannon Morrison, Ben Davies, Igor Konstantinov, Stephen Horton, Stephen Bottrell, Andrew Davidson, Vera Ignjatovic, Paul Monagle, Chantal Attard, Department of Anaesthesia and Pain Management, The Royal Children, s Hospital, Department of Paediatrics, The University of Melbourne, Haematology Research, Murdoch Children, s Research Institute, Anaesthesia Research, Murdoch Children, s Research Institute, Department of Cardiac Surgery, The Royal Children, s Hospital, Heart Research, Murdoch Children, s Research Institute, Department of Clinical Haematology, The Royal Children, s Hospital

Perfusion

Published online on November 01, 2025

Abstract

Perfusion, Ahead of Print.
IntroductionHeparin is usually added to infant cardiopulmonary bypass circuit primes. Ultrafiltration is often used to minimise prime volume before commencing bypass. The extent of heparin removal from bypass primes by ultrafiltration is unknown, however ...