Investigating the epigenetic basis for aortic aneurysm risk in patients with bicuspid aortic valve disease

Abdul Badran, Christopher J Goulden, Amer Harky, Narain Moorjani, Sunil Ohri, Wessex Department of Cardiothoracic Surgery, University Hospital Southampton, University of Southampton, School of Medicine, University of Liverpool, Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Department of Cardiothoracic Surgery, Papworth Hospital, University of Cambridge

Perfusion

Published online on August 07, 2025

Abstract

Perfusion, Ahead of Print.
BackgroundBicuspid aortic valve (BAV) is a common congenital cardiac malformation associated with significant morbidity, including aortic dissection and thoracic aortic aneurysms. The mechanisms underlying BAV-associated aortopathy are unknown. We aimed ...