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Implementing response-adaptive randomisation in stratified rare-disease trials: Design challenges and practical solutions

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Statistical Methods in Medical Research: An International Review Journal

Published online on

Abstract

Statistical Methods in Medical Research, Ahead of Print.
Although response-adaptive randomisation (RAR) has gained substantial attention in the literature, it still has limited use in clinical trials. Amongst other reasons, the implementation of RAR in real world trials raises important practical questions, ...