A real-world study on the comparative effectiveness of first-line treatment regimens in advanced NSCLC patients with PACC mutations
Therapeutic Advances in Medical Oncology
Published online on April 20, 2026
Abstract
Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:P-loop and αC-helix compressing (PACC) mutations are a distinct structural subset of atypical epidermal growth factor receptor (EGFR) alterations in non-small-cell lung cancer (NSCLC), yet no standard first-line strategy has been established....
Background:P-loop and αC-helix compressing (PACC) mutations are a distinct structural subset of atypical epidermal growth factor receptor (EGFR) alterations in non-small-cell lung cancer (NSCLC), yet no standard first-line strategy has been established....