Clinically relevant somatic variants and genomic discordance between primary tumors and mediastinal lymph nodes in lung adenocarcinoma

Caroline Silvério Faria, Camila Machado Baldavira, Tabatha Gutierrez Prieto, Ilka Lopes Santoro, Viviane Rossi Figueiredo, Ellen Caroline Toledo do Nascimento, Leslie Domenici Kulikowski, Teresa Yae Takagaki, Murilo Cervato, Ricardo Mingarini Terra, Vera Luiza Capelozzi, Leila Antonangelo

Therapeutic Advances in Medical Oncology

Published online on January 30, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:Histopathological evaluation, TNM classification, and mediastinal staging via endobronchial ultrasound-guided transbronchial needle aspiration provide essential guidance for therapeutic decision-making in non-small cell lung cancer (NSCLC). ...