Sequential or upfront triple combination with durvalumab, tremelimumab, and bevacizumab for patients with unresectable hepatocellular carcinoma: the MONTBLANC trial protocol (AIO-HEP-0325/ass)

Najib Ben Khaled, Ursula Ehmer, Ilja Kubisch, Maria A. Gonzalez-Carmona, Alexander Philipp, Max Seidensticker, Julia Altenhofer, Marion Basch, Tim Hüwer, Bettina Oehrle, Andreas Geier, Caterina Soldà, Alessandra Auriemma, Ulrike Bauer, Taotao Zhou, Lukas Perkhofer, Jack Chater, Arndt Weinmann, Johann von Felden, Antonio De Rosa, Caterina Vivaldi, Ignazio Piseddu, Isabel Schwald, Stefan Enssle, Monika Karin, Julia S. Schneider, Moritz N. Gröper, Katarina Ondrejkova, Lena Weiss, Georg Beyer, Kornelius Schulze, Lorenzo Antonuzzo, Gianluca Masi, Bruno Daniele, Jens Ricke, Julia Mayerle, Friedrich Foerster, Florian P. Reiter, Thomas J. Ettrich, Enrico N. De Toni

Therapeutic Advances in Medical Oncology

Published online on February 21, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:Immune checkpoint inhibitor (ICI)-based combination therapy has transformed the therapeutic landscape of advanced hepatocellular carcinoma (aHCC). However, durable clinical benefit remains limited to a subset of patients, highlighting the need ...