Efficacy and safety of PARP inhibitors in metastatic breast cancer patients with homologous recombination repair pathway gene mutations: a retrospective multicenter real-world study

Xuenan Peng, Ruixia Song, Ying Fan, Jiayu Wang, Qiao Li, Hongnan Mo, Jiani Wang, Yang Luo, Shanshan Chen, Xiaoying Sun, Jintao Zhang, Pin Zhang, Binghe Xu, Bo Lan, Fei Ma

Therapeutic Advances in Medical Oncology

Published online on January 02, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:The efficacy and safety of poly (ADP-ribose) polymerase inhibitors (PARPis) in the Chinese real-world setting have not been well characterized.Design:This is a retrospective analysis of PARPis efficacy in metastatic breast cancer (MBC) patients ...