Oligonucleotides: Evolution of Carcinogenicity and Risk Assessment Strategy
Published online on March 31, 2026
Abstract
Toxicologic Pathology, Ahead of Print.
Since 2006, the carcinogenic potential of antisense oligonucleotides (ASOs) has primarily been evaluated using standard 2-year rodent bioassays. To date, no human-relevant tumor findings have been identified across nonclinical ASO studies. As the field ...
Since 2006, the carcinogenic potential of antisense oligonucleotides (ASOs) has primarily been evaluated using standard 2-year rodent bioassays. To date, no human-relevant tumor findings have been identified across nonclinical ASO studies. As the field ...