Knockout of histone deacetylase 6 exacerbates PM2.5-induced pulmonary injury by affecting renin-angiotensin system balance in mice

Yang Zhang, Lifang Jin, Caixia Fan, Guoquan Fu, Huarong Huang, Junyan Yan, School of Life and Environmental Sciences, Shaoxing University, Neuroimmunology Department, Hangzhou Hongwang Medical Laboratory Co, College of Life and Environmental Science, Hangzhou Normal University

Toxicology and Industrial Health

Published online on April 21, 2026

Abstract

Toxicology and Industrial Health, Ahead of Print.
Fine particulate matter (PM2.5) deposition in the lungs can induce pulmonary injury. Histone deacetylase 6 (HDAC6), a critical member of the histone deacetylase family, plays a key role in regulating lung diseases. In this study, we explored the mechanism ...