The role of doxycycline in reducing MMP-9 and acute-phase reactants to limit abdominal aortic aneurysm growth: A systematic review

Luis Morales-Ojeda, Stefania Montero-Arcila, Leetha Paul, Victor Nunes, Emily A. Malgor, Donald L. Jacobs, Rafael D. Malgor, Department of Vascular Surgery , Endovascular Therapy, University of Colorado Anschutz Medical Center, Department of Surgery, University of Colorado Anschutz Medical Center, Instituto Dante Pazzanese de Cardiologia, Sao Pablo

Vascular

Published online on October 31, 2025

Abstract

Vascular, Ahead of Print.
BackgroundAbdominal aortic aneurysms (AAAs) are a significant vascular disease characterized by the degradation of medial elastic lamellae, neovascularization, and inflammatory responses. While surgical intervention remains the standard treatment for ...