Ascorbate and alpha-tocopherol attenuate hepatorenal injury and modulate CYP2E1 and Nrf2 expression in rats exposed to herbalised alcoholic beverage

Temidayo Daniel Adeniyi, Akinpelu Moronkeji, Godwin Olawoyin Adunmo, Adetokunbo Adedotun Okunnuga, Olayinka Joshua Ajala, Abiodun Oyeleke, Puritan Chinonso Umeboro, Oluwatimilehin Kemisola Thomas, Department of Medical Laboratory Science, Faculty of Basic Clinical Sciences, University of Ilorin, Kwara State, Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osun State, Medical Laboratory Services, Department of Morbid Anatomy and Histopathology, Federal Teaching Hospital, Ekiti State, Department of Internal Medicine, Kent and Canterbury Hospital, Department of Anatomy, Faculty of Basic Medical Sciences, Federal University, Ekiti State, Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Elizade University, Ilara- Mokin, Ondo State

Human & Experimental Toxicology

Published online on May 06, 2026

Abstract

Human & Experimental Toxicology, Volume 45, January-December 2026.
BackgroundThe rising consumption of herbal alcoholic beverages in Nigeria, driven by unverified health claims, poses growing public health risks and adds to the global disease burden.AimTo evaluate the effects of ascorbate and alpha-tocopherol ...