Longitudinal short-term assessments of single- and multi-protein disease activity biomarkers to determine reliability and the minimum detectable change in people with clinically stable RRMS

Shannon McCurdy, Elisa Sheng, Kian Jalaleddini, Gargi Datta, Tamara Shabi, Annalise E Miner, Alexander Hari, Srushti Tiwari, Wayne Hu, Franklin Faust, Kelly Leyden, Sarah Eagleman, David M Brazel, Terrie Livingston, Ferhan Qureshi, Jennifer S Graves

Multiple Sclerosis Journal

Published online on May 07, 2026

Abstract

Multiple Sclerosis Journal, Ahead of Print.
Objectives:This study aims to evaluate the ability of a multi-protein biomarker score to characterize clinical stability in relapsing-remitting multiple sclerosis (RRMS) compared to that of single-protein markers.Methods:Serum was collected from 62 out of ...