Kappa free light chain index or oligoclonal bands testing in clinical practice for multiple sclerosis diagnosis: An algorithm comparative study

Michaël Levraut, Mikael Cohen, Delphine Sterlin, Xavier Ayrignac, Kévin Bigaut, Hélène Zéphir, Jonathan Ciron, Jean-Philippe Camdessanché, Olivier Casez, Thibault Moreau, Elisabeth Maillart, Aude Maurousset, David Laplaud, Edith Bigot, Jean Pelletier, Eric Thouvenot, Christine Lebrun-Frénay, on behalf of SFSEP , Société Francophone de la Sclérose en Plaques

Multiple Sclerosis Journal

Published online on May 07, 2026

Abstract

Multiple Sclerosis Journal, Ahead of Print.
Background:Limited evidence exists on how to use kappa free light chains (κFLCs) and oligoclonal bands (OCBs) in diagnosing intrathecal immunoglobulin synthesis (IgS).Objective:To compare different algorithms to define IgS.Methods:A retrospective analysis ...